Ratio Spectra Derivative and Zero-Crossing Difference Spectrophotometric Determination of Olmesartan Medoxomil and Hydrochlorothiazide in Combined Pharmaceutical Dosage Form
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منابع مشابه
Simultaneous Determination of Losartan and Hydrochlorothiazide in Pharmaceutical Preparations by Derivative and Ratio Derivative Spectrophotometry
Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...
متن کاملSpectrophotometric Estimation of Olmesartan Medoxomil and Hydrochlorothiazide in Tablet
A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan medoxomil and hydrochlorothiazide respectively. The proposed method was validate...
متن کاملDerivative and Q-analysis Spectrophotometric Methods for Estimation of Hydrochlorothiazide and Olmesartan Medoxomil in Tablets
Two methods for simultaneous estimation of hydrochlorothiazide and olmesartan medoxomil in combined tablet dosage form have been developed. The first method is the application of Q-analysis method (absorbance ratio), which involves the formation of Q-absorbance equation at 264 nm (isobestic point) and at 271 nm, the maximum absorption of hydrochlorothiazide. The linearity ranges for hydrochloro...
متن کاملThree Multivariate Calibration Methods for Simultaneous Spectrophotometric Determination of Olmesartan Medoxamil, Amlodipine Besylate and Hydrochlorothiazide in Their Combined Dosage Form
Olmesartan medoxamil (OLM, an angiotensin II receptor blocker), amlodipine besylate (AML, a dihydropyridine calcium channel blocker) and hydrochlorothiazide (HCT, a diuretic of the class of benzothiadiazines) are co-formulated in a single-dose combination for the treatment of hypertensive patients whose blood pressure is not adequately controlled on either component monotherapy. In this work, t...
متن کاملRapid Simultaneous Determination of Olmesartan, —Amlodipine and Hydrochlorothiazide in Combined Pharmaceutical Dosage form by Stability-Indicating Ultra Performance Liquid Chromatography
A simple, precise and rapid stability-indicating ultra-performance liquid chromatography (UPLC) method was developed for the simultaneous quantitative determination of Olmesartan, Amlodipine and Hydrochlorothiazide from their innovative Pharmaceutical combination drug product, with the presence of degradation products. It involved a 50 mm × 2.1 mm, 1.8 μm Phenyl column. The separation was achie...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2009
ISSN: 1530-9932
DOI: 10.1208/s12249-009-9318-y